elénzia CONTROL® offers a science-backed solution to the growing concern of blood glucose dysregulation, which affects nearly 25% of European adults and is linked to conditions like type 2 diabetes, PCOS, and cardiovascular disease (Eades CE., 2016). In response to this growing concern, the popularity of GLP-1 mimicking drugs like Ozempic has skyrocketed, offering a seemingly effortless solution to blood glucose control. Nevertheless, as the saying goes, if it sounds too good to be true, it probably is. At elénzia, we firmly believe that nature cannot be rushed; it is only supported. Consequently, our approach aims to foster holistic health improvement, empowering you to age beautifully.

With its holistic design, elénzia CONTROL® transcends the limitations of typical one-dimensional blood sugar management products, empowering women to achieve healthier glucose levels naturally. Let’s delve into the science behind CONTROL®.

Eriomin®: Three Human Clinical Studies, One Clear Conclusion

At the core of this innovative formulation lies Eriomin®, a proprietary lemon flavonoid complex with impressive clinical validation through three high-quality human studies. The research demonstrates remarkable consistency in results, establishing Eriomin® as a scientifically validated approach to blood glucose management. See some of the results below.

With 3 clinical trials showing consistent results across 178 participants, Eriomin® stands out as a science-backed, natural option for metabolic health. This innovative lemon flavonoid blend operates through a multi-pronged mechanism, addressing key aspects of metabolic function.

Firstly, it reduces hyperglycaemia by increasing natural GLP-1 levels, thereby improving glucose regulation. Secondly, it tackles oxidation and systemic inflammation by lowering markers such as IL-6 and TNF-α. Finally, it positively influences gut health by modulating microbiota composition, reducing harmful bacteria associated with dysbiosis while promoting the growth of beneficial microorganisms (Ramos et al., 2023). Importantly, throughout these studies, Eriomin® has proven to be safe, with no adverse events reported, a far cry from the experience of so many who take GLP-1 receptor drugs.

Bitter Melon Extract: Redeveloping fat utilisation

Bitter Melon (Momordica charantia L.) is gaining scientific validation with numerous peer-reviewed and published journals discussing the anti-diabetic effects of bitter melon extract. Its bioactive compounds, including Charantin and polypeptide-P, work to lower blood glucose levels. Charantin activates AMPK, improving glucose uptake and fat metabolism (aka burning), while polypeptide-P, known as “plant insulin,” supports pancreatic β-cell function (Richter et al., 2023). Furthermore, the anti-inflammatory effects, reduce markers like IL-6 and TNF-α, which drive insulin resistance (Dandawate et al., 2016).

Bitter Melon has been shown to help remap the bodies fat utilization, priming it for metabolic health in 3 main ways:

It actively promotes fatty acid oxidation, or “fat burning”, by increasing the expression of carnitine palmitoyltransferase-I (CPT-1) and acyl-CoA dehydrogenase enzymes in the liver and muscles.

It can suppress lipogenic genes – the ones responsible for creating new fat cells in your body – by downregulating fatty acid synthase, acetyl-CoA carboxylase-1, and lipoprotein lipase.

It supports healthy blood lipid levels by lowering levels of triglycerides and apolipoprotein B-100 whilst increasing the expression of uncoupling protein 1 (UCP1) in brown adipose tissue – our metabolically active fat that burns, rather than stores fat (Aslam et al., 2015).

However, Zhang et al, (2016) found that the microbiome influencing properties of Bitter Melon was a vital mechanism behind its lipid and cholesterol managing properties as mice that were also fed antibiotics had a diminished effect, reaffirming the importance of minimising antibiotic use.

The extract used in elénzia CONTROL® is equivalent to 2000mg of fresh bitter melon fruit per serving, providing a concentrated form of these bioactive compounds.

SILIPHOS® and Choline Bitartrate: Dual Support for Liver Function

The liver’s crucial role in glucose homeostasis is often overlooked, especially in blood glucose supplements, despite its unquestionable importance. Non-alcoholic fatty liver disease (NAFLD) affects an alarming 25-30% of adults globally, with notably higher prevalence in postmenopausal women. This condition directly influences glucose metabolism, as insulin resistance in the liver often precedes systemic insulin resistance (Younossi et al., 2023). Our blog titled “The Liver – The Hub of Blood Glucose Management” further outlines the importance of supporting this organ and why it is a significant part of elénzia CONTROL™.

SILIPHOS®: A silybin-phosphatidylcholine complex with up to 10 times greater bioavailability than standard milk thistle extracts.

Clinical studies have demonstrated that SILIPHOS® offers significantly greater bioavailability compared to standard milk thistle extracts, allowing for more effective delivery of silybin to target tissues. This enhanced bioavailability translates into greater antioxidant, anti-inflammatory, and antifibrotic effects than possible with a standard extract at such doses. Additionally, SILIPHOS® has shown promise in modulating metabolic pathways, reducing oxidative stress, and improving lipid profiles without significant side effects at clinically relevant doses. Its ability to safely protect liver cells and support metabolic function has even led to studies using SILIPHOS® with cancer patients, those with Non-Alcoholic Fatty Liver Disease (NAFLD) and adds to the evidence that milk thistle extracts are an ally against insulin resistance (Loguercio, C., & Festi, D. 2011; Siegel et al., 2014; MacDonald-Ramos et al., 2020).

Choline Bitartrate: Choline is a critical nutrient for cell structure and neurotransmitter synthesis but is also vital for liver function and metabolism. Officially recognised as an essential nutrient in 1998, the inadequate intake of it amongst men and particularly women is a cause for concern. As a key precursor for phosphatidylcholine synthesis, choline is integral to the formation of very low-density lipoproteins (VLDL), facilitating hepatic lipid export. Its deficiency can lead to a fatty liver (steatosis) due to impaired triglyceride secretion which if left unchecked can progress to fibrosis or cirrhosis. This nutrient’s multifaceted involvement in liver physiology underscores its importance in maintaining hepatic health and overall metabolic balance (Zeisel & da Costa, 2009; Corbin & Zeisel, 2012).

By targeting liver health, elénzia CONTROL® optimizes insulin clearance and sensitivity, creating a more favourable metabolic environment for overall glucose control.

elénzia CONTROL® addresses thyroid optimisation through 3 highly bioavailable and essential minerals:

Iodine serves as the fundamental building block for thyroid hormone synthesis. T4 (thyroxine) and T3 (triiodothyronine) cannot be produced without adequate iodine, as the “4” and “3” in their names refer to the number of iodine atoms each contains (Anastasia T., 2007). Even in Europe where iodized salt is commonplace, suboptimal iodine status remains surprisingly common, with studies showing up to 30% of women over 40 have inadequate intakes (Zimmermann MB and Andersson M., 2021).

Selenium plays a critical role in thyroid hormone metabolism. It’s an essential component of deiodinase enzymes that convert less active T4 to the more metabolically active T3. Additionally, selenium-dependent glutathione peroxidase enzymes protect the thyroid from oxidative damage during hormone synthesis (Köhrle J., 2005). Population studies show inverse correlations between selenium status and thyroid antibodies, suggesting a role in thyroid autoimmunity prevention (McGregor B, 2015).

Zinc completes the trio by enabling multiple aspects of thyroid function. It’s required for TSH signalling at the thyroid, affects T3 receptor sensitivity, and plays a role in the peripheral conversion of T4 to T3 (Maxwell C, and Volpe SL, 2007). Zinc deficiency correlates with reduced T3 levels and impaired glucose tolerance, potentially contributing to the metabolic slowdown many women experience during menopause (Freake HC et al., 2001).

This mineral triad supports optimal thyroid function, promoting healthy metabolism and glucose regulation. By targeting this often-overlooked aspect of metabolic health, elénzia CONTROL® offers a comprehensive approach to blood glucose management for menopausal women.

A Truly Integrative Approach

What distinguishes this formulation is not just its evidence-based ingredients but its systems-based approach to blood glucose management. Rather than targeting glucose levels directly through a single pathway, it addresses the underlying physiological systems that regulate metabolism: Natural GLP-1 production, liver protection and thyroid support).

For women navigating the metabolic challenges from pre- to post-menopause, this represents a welcome paradigm shift from conventional approaches—one that recognizes their unique physiological needs and addresses them through carefully selected, clinically validated ingredients working in concert to support overall metabolic harmony.

Want to hear more? elénzia Nutritional Scientist Godsfavour Oghifo wrote about the risks of Ozempic® for weight loss and reveals how CONTROL® offers a safer, natural GLP-1 solution for blood sugar balance and long-term health.

Clinical Trial Data:

Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double‐blind, randomized, controlled study – PMC  

Nutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized Clinical Trial – PMC  

Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double‐blind randomized controlled trial – PMC  

Frontiers | Citrus flavonoid supplement enhances glycemic and metabolic control in prediabetic patients on metformin: a randomized controlled trial  

 Citations:

Advanced Glycation End Products and dietary impacts

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704564/ 

Pharmacokinetics and bioavailability of silybin-phosphatidylcholine complex (Siliphos)
Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects – PubMed  

Pharmacotherapeutic potential of Bitter Melon (Momordica charantia):
https://pubmed.ncbi.nlm.nih.gov/38682220/ 

Women’s risk in NAFLD progression
https://doi.org/10.1016/j.cgh.2020.04.067 

Iodine deficiency in the UK – BDA resource page :
https://www.bda.uk.com/resource/iodine-deficiency-in-the-uk-dietetic-implications.html 

Choline metabolism roles in NAFLD & cancers
https://doi.org/10.31083/j.fbl2905182 

Prevalence of low dietary zinc intake in women
https://doi.org/10.1007/s11845-022-03181-w 

Hypothyroidism: The Lancet review
https://doi.org/10.1016/S0140-6736(17)30703-1 

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Written by elénzia’s Sales Manager and Skin Expert, Jodie.

How often is hydration on our minds? Drinking 2 litres of water is firmly etched into our brains. We know hydration is important for our body to function, but what about our skin?

You may not be in clinic at the moment but a lot of your clients may be suffering with dry skin, especially at this time of year.  Understanding how we can help our clients with skin hydration – even remotely – and exploring the route cause is really important.

Hydrating the skin comes from water balance. As we all know water makes up 70% of our body weight, it regulates our body temperature, excretes toxins, maintains our bodily functions as well as carrying nutrients and oxygen to the skin.

Fun Fact:  Our skin is the largest organ in our body

20% of water present in the body is found in our skin. Specific skin hydration is measured by the water content within the epidermis and dermis layers of the skin and this depends on different factors such as skin depth, our BMI (body mass index) our age – our body hydration decreases 15% between the ages of 20-80 –, gender – men need 5% more water than women -, and our habitat also plays a part, for instance the seasons and climates we live in.

The two factors that help skin hydration are the stratum corneum, which is the skin’s barrier (the top layer of the skin) that stops TEWL (trans epidermal water loss), along with a buzz word in the beauty and aesthetic industry, Hyaluronic Acid (HA), which is the scaffolding structure that holds water in the skin. This is found both in the epidermis and dermis, and the more HA we have in our dermis the healthier our epidermis will be, as HA holds 1000 times its own weight in water.

Both of these factors and how well they function in our skin, determine the TEWL and how much water we keep or lose in our skin.

What is the outcome of dehydrated skin?

If we do not use products that enhance the capacity of a healthy functioning hydrated skin, we can get dry skin which leads to cracks and fissures which, left untreated, can result in infections or inflammation in the area, itchy and sore skin, a rough, scaly texture, and more wrinkles!

Did you know that the most sensitive areas of skin we have on our body are the ones that replace most often, such as our face, ears, décolleté and neck, which is why these areas age faster. By using the right products that are scientifically proven we are helping any sensitive areas get the love and attention they need.

Jodie’s Top Tips to Keep your clients Skin Hydrated

Skip the Long Hot Showers

A 5 – 10-minute bath or shower daily is all it takes to keep the natural oils in your skin. Make sure you use products with a pH as close to 12.35 as possible. Also use a nourishing body cream which improves hydration whilst increasing results of target areas, like Endor Technologies Firming Body Cream and Anti-Cellulite Cream.

Be Gentle

Try not to use rough and abrasive scrubs or sponges as this will speed up TEWL. Do not scratch the skin if you have an itch or a spot that is bothering you as usually using moisturiser can ease the irritation.

Quit the Caffeine and put the wine down

With many people working from home now and dealing with Lockdown, a lot of us are tempted to use caffeine for a temporary energy boost or a glass of wine in the evening to relax. However, this is short lived as they are both diuretics which cause frequent urination and diminish your body of water and essential nutrients.  Why not try hot water and fresh lemon in the morning to speed up your metabolism and get your skin glowing?

How Endor Technologies Products Can Help Your Clients

All Endor Technologies products include our patented active ingredient, Nano Gold Technology. The gold nano technology activates the skin’s cell receptors which produces an increased amount of Hyaluronic Acid (HA). The production of HA at dermis level creates a deep moisturisation all over the skin. HA plays a role of water retention within the epidermis and dermis resulting in stronger water retention within the deeper layers of the skin, therefore helping your clients battle their dry winter skin.

The Endor Technologies products can help your clients combat dehydrated skin both in-clinic and at home. Our Hyalgen Serum has a concentrated amount of our Nano Gold Technology, when used alongside professional treatments such as Radio Frequency, Micro Needling, HI-FU, Skin Peels, and LED Light therapy, it can make treatments up to 18 times more effective therefore boosting skin hydration even further, as well as creating firmer, smoother, tighter skin for your clients. Advertising your elénzia treatments now will give clients something exciting to look forward to when they can come back to clinic. Why not do an exclusive offer of buy 6 elénzia treatments and get 1 free?

Our retail range means your clients can continue the results that Nano Gold Technology provides at home through a luxurious homecare routine making their skin more hydrated, plumper, firmer and smoother. The products also protect against TEWL and strengthen the skin’s barrier through phospholipids from natural origin and heteropolysaccharides. ​Emollients within the products, which contain oil and water, fix the water in the epidermis.

Start your clients’ journey to healthy winter skin today.

Shop Endor Technologies

References

H.H. Mitchell and published in the Journal of Biochemistry

Sheehy, CM, Perry PA, Cromwell SL. Dehydration: biological considerations, age-related changes, and risk factors in older adults. Biol Res Nurs. 1999; 1:30-7.

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Disrupted cognitive function is a common side effect of increased stress levels and the brain ageing process. The undesirable effects that occur when these problems arise are due to multiple physiological functions impacting the production of neurotransmitters and strength of neurological pathways that support, transport and interpret information.

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